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KMID : 0359320090490040345
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Korean Journal of Veterinary Research
2009 Volume.49 No. 4 p.345 ~ p.349
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Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes
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Han Dae-Yong
Park Kwang-Il
Park Hyeon-Soo
Kang Sang-Rim
Cho Jae-Hyeon
Lee Hu-Jang
Kim Eun-Hee
Kim Gon-Sup
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Abstract
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Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,3´,4,4´,5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.
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KEYWORD
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COX-2, cPLA2, PCB118, proinflammatory effect
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